Date: 1664

"And finally, when a rational soul is present in this machine it will have its principal seat in the brain, and reside there like the fountain-keeper who must be stationed at the tanks to which the fountain's pipes return if he wants to produce, or prevent, or change their movements in some way."

— Descartes, René (1596-1650)

Date: 1691

"Thirdly, Let us hence duly learn to prize and value our Souls; is the Body such a rare Piece, what this is the Soul? the Body is but the Husk or Shell, the Soul is the Kernel; the Body is but the Cask, the Soul the precious Liquor contained in it; the Body is but the Cabinet; the Soul the Jewel;...

— Ray [formerly Wray], John (1627–1705)

Date: 1701

"Man is a Creature of so mixed a Composure, and of a Frame so inconsistent and different from Itself, that it easily speaks his Affinity to the highest and meanest Beings; that is to say, he is made of Body and Soul, he is at once an Engine and an Engineer."

— Steele, Sir Richard (1672-1729)

Date: 1733

"I have formerly suggested, that the best Similitude I can form of the Nature and Actions of this Principle upon the Organs of its Machin, is that of a skillful Musician playing on a well-tun'd Instrument."

— Cheyne, George (1671-1743)

Date: 1751

"The sympathy, therefore, or consent observed between the nerves of various parts of the body, is not to be explained mechanically, but ought to be ascribed to the energy of that sentient being, which seems in a peculiar manner to reside in the brain, and, by means of the nerves, moves, actuates,...

— Whytt, Robert (1714-1766)